Parkinson disease: Gut reactions—can changes in the intestinal microbiome provide new insights into Parkinson disease?

Abstract

The investigators found a 77.6% reduction in abundance of Prevotellaceae in the faeces of patients with PD compared with controls. By contrast, five other families of bacteria were more scarce in controls than in patients with PD. On the basis of Prevotellaceae levels alone, patients with PD could be identified with high sensitivity (86.1%) but low specificity (38.9%). “Within the PD group, abundance of Enterobacteriaceae was related to the severity of postural instability and gait difficulty,” adds Scheperjans. “So, there was a connection between gut microbiota and the motor phenotype of our patients.” Evidence is emerging that the vagus nerve provides a conduit for the spread of α-synuclein pathology from the enteric PARKINSON DISEASE

DOI: 10.1038/nrneurol.2014.256

Cite this paper

@article{Wood2015ParkinsonDG, title={Parkinson disease: Gut reactions—can changes in the intestinal microbiome provide new insights into Parkinson disease?}, author={Heather D Wood}, journal={Nature Reviews Neurology}, year={2015}, volume={11}, pages={66-66} }