Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow.

@article{Cohen1997ParkinsonDA,
  title={Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow.},
  author={G G Cohen and Rizwan Farooqui and N Kesler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 10},
  pages={4890-4}
}
Two factors that contribute to the progression of Parkinson disease are a brain defect in mitochondrial respiration and the generation of hydrogen peroxide (H2O2) by monoamine oxidase (MAO). Here we show that the two are linked. Metabolism of the neurotransmitter dopamine, or other monoamines (benzylamine, tyramine), by intact rat brain mitochondria suppresses pyruvate- and succinate-dependent electron transport. MAO inhibitors prevent this action. Mitochondrial damage is also reversed during… CONTINUE READING
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Cohen et al

  • D. A. Di Monte, P. Chan, Sandy, 32 M.S.Ann.Neurol., S111–S115. 4894 Biochemistry
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

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