Parkinson disease: Could over-the-counter treatment protect against Parkinson disease?
@article{Mcsharry2011ParkinsonDC, title={Parkinson disease: Could over-the-counter treatment protect against Parkinson disease?}, author={Carolyn Mcsharry}, journal={Nature Reviews Neurology}, year={2011}, volume={7}, pages={244-244} }
In a large prospective study, Gao and his colleagues investigated the use of NSAIDs in 136,197 individuals from two cohorts— the Health Professionals Follow-up Study and the Nurses’ Health Study. All participants were free of PD at baseline, and were followed up for 6 years. During this time, 291 cases of PD emerged. Using questionnaires to obtain patients’ self-reported analgesic use, the researchers observed a dose–response relationship between the amount of ibuprofen taken PARKINSON DISEASE
3 Citations
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Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import
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It is shown that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster, indicative of conserved eukaryotic longevity effects and points to fundamental cell cycle signatures linked with longevity.
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References
Use of ibuprofen and risk of Parkinson disease
- MedicineNeurology
- 2011
The association between use of ibuprofen and lower PD risks, not shared by other NSAIDs or acetaminophen, suggests ib uprofen should be further investigated as a potential neuroprotective agent against PD.