Parkinson disease, LRRK2 and the endocytic-autophagic pathway.

  title={Parkinson disease, LRRK2 and the endocytic-autophagic pathway.},
  author={Javier Alegre-Abarrategui and Richard Wade-Martins},
  volume={5 8},
Neurons are quiescent cells that survive for several decades, many times the turnover time of most organelles and proteins, and so with advancing age neurons become affected by degenerative diseases. Autophagy is thought to be an important cellular mechanism preventing cell degeneration in such long-lived cells. We have recently found that the Parkinson disease (PD) gene leucine rich repeat kinase 2 (LRRK2) is directly involved in this process by acting as a negative regulator of autophagic… CONTINUE READING


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