Parkinson Disease and Dementia

  title={Parkinson Disease and Dementia},
  author={Sara Garc{\'i}a-Ptacek and Milica Kramberger},
  journal={Journal of Geriatric Psychiatry and Neurology},
  pages={261 - 270}
Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances… 

Parkinson's Disease: Cognitive Impairment.

Since cognitive dysfunction is underdetected and undertreated in clinical practice, holistic psychiatric care of PD patients warrants appreciation of the clinical presentation, biopsychosocial features, and treatment of cognitive impairment.

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

A critical overview of dementia syndromes that overlap in many clinical features, genetics, neuropathology, and management is provided, suggesting that they share important common underlying molecular pathogenesis with Alzheimer’s disease and other proteinopathies.

Lewy Body Dementias: A Coin with Two Sides?

An overview of the neuropathological and clinical features, current diagnostic criteria, biomarkers, and management of LBD is provided, with a special focus on α-synuclein markers.

Novel clinicopathological characteristics differentiate dementia with Lewy bodies from Parkinson’s disease dementia

Cerebral amyloid angiopathy (CAA), often seen in AD, is increasingly recognized for its association with dementia.

Available and future treatments for atypical parkinsonism. A systematic review

  • D. Moretti
  • Medicine
    CNS neuroscience & therapeutics
  • 2019
The present work overviews the most influential research literature collected on MEDLINE, ISI Web of Science, Cochrane Library, and Scopus for available treatment in atypical parkinsonisms without time restriction.

Review: Clinical, neuropathological and genetic features of Lewy body dementias

The aim of this article is to review the main clinical, neuropathological and genetic aspects of dementia with Lewy bodies and Parkinson's disease dementia, particularly relevant as future management for these two conditions may differ.

Psychosis Management in Lewy Body Dementia: A Comprehensive Clinical Approach

Goal of care and functional assessment are a crucial part of the optimized care plan, given overall guarded prognosis, in the context of numerous complications observed in this population of dementia patients.

Dementia-Related Functional Disability in Moderate to Advanced Parkinson’s Disease: Assessment Using the World Health Organization Disability Assessment Schedule 2.0

It is suggested that deteriorating social relationships were a dementia-related disability in all PwP at the moderate and advanced disease stages and could indicate cognitive impairment in people with moderate or advanced PD.

Assessment of individual cognitive changes after deep brain stimulation surgery in Parkinson’s disease using the Neuropsychological Test Battery Vienna short version

Roughly 10% of DBS patients showed cognitive decline mainly affecting the domains attention and executive functioning (phonemic fluency), and further research is needed to identify the mechanisms that lead to improvement or deterioration of cognitive functions in individual cases.



The Epidemiology of Dementia Associated with Parkinson's Disease

The purpose of this review is to present recent findings on clinical aspects of dementia in PD and to elucidate underlying clinical and neurobiological risk factors.

Cognitive impairment in Parkinson's disease and dementia with Lewy bodies.

  • D. Aarsland
  • Psychology, Medicine
    Parkinsonism & related disorders
  • 2016

Recognition and treatment of neuropsychiatric disturbances in Parkinson’s disease

The non-motor symptoms of Parkinson’s disease (PD) have been attracting increasing attention due to their ubiquitous nature and their often devastating effects on the quality of life. Behavioral

The spectrum of cognitive impairment in Lewy body diseases

The spectrum and evolution of cognitive impairment in Lewy body disorders is examined and the conundrum of whether Parkinson's disease dementia and dementia with Lewy bodies represent the same or different entities remains unresolved.

Cognitive impairment and dementia in Parkinson's disease

Cognitive Predictors of Dementia in Parkinson’s Disease: A Community-Based, 4-Year Longitudinal Study

It was concluded that poor performance on a test sensitive to executive dysfunction predicted later development of dementia in PD patients, and this finding may have important clinical implications as a marker of subsequentDevelopment of dementia.

The neurobiological basis of cognitive impairment in Parkinson's disease

Critical assessment of animal models shows that chronic low‐dose MPTP treatment in primates recapitulates PD‐MCI over time, enhancing the current biological concept of PD‐ MCI as having enhanced dopamine deficiency in frontostriatal pathways as well as involvement of other neurotransmitter systems.

Clinical diagnostic criteria for dementia associated with Parkinson's disease

  • M. EmreD. Aarsland B. Dubois
  • Psychology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2007
Clinical diagnostic criteria for probable and possible PD‐D are proposed, characterized by impairment in attention, memory, executive and visuo‐spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent.