Parkinson Disease Genetics: A "Continuum" from Mendelian to Multifactorial Inheritance.

Abstract

Parkinson Disease (PD) is a common neurodegenerative disorder of intricate etiology, caused by progressive loss of aminergic neurons and accumulation of Lewy bodies. The predominant role of genetics in the etiology of the disease has emerged since the identification of the first pathogenetic mutation in SNCA (alpha-synuclein) gene, back in 1997. Mendelian… (More)
DOI: 10.2174/1566524014666141010155509

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