Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity

  title={Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity},
  author={Dag Aarsland and Elisabet Londos and Clive G Ballard},
  journal={International Psychogeriatrics},
  pages={216 - 219}
The combination of dementia and parkinsonism is common and distressing, and dementia associated with Parkinson’s disease (PDD) and dementia with Lewy bodies (DLB) are the most common causes. By definition, in PDD, dementia develops after more than one year with parkinsonism, whereas in DLB, dementia occurs before, simultaneously with, or within one year of the onset of parkinsonism. Whereas there are obvious clinical challenges in defining the exact timing of onset of two insidiously developing… 
Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
A critical overview of dementia syndromes that overlap in many clinical features, genetics, neuropathology, and management is provided, suggesting that they share important common underlying molecular pathogenesis with Alzheimer’s disease and other proteinopathies.
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  • 2017
Both DLB and PDD show heterogeneous pathology and neurochemistry, suggesting that they share important common underlying molecular pathogenesis with AD and other proteinopathies, and there remains a pressing need to differentiate them more clearly.
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  • 2018
Dementia with Lewy bodies and Parkinson's disease dementia may best be viewed as two distinct entities
The evidence is presented to support the argument that DLB and PDD should be considered separately from a clinical, neuropathologic, neuroradiologic, and neurochemical perspective.
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Combined analysis of imaging and cerebrospinal fluid markers (tau and Aβ-42) is the most promising method for indentifying PD-MCI and PDD.
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