Parkinson's disease

  title={Parkinson's disease},
  author={A. Lees and J. Hardy and T. Revesz},
  journal={The Lancet},
  • A. Lees, J. Hardy, T. Revesz
  • Published 2006
  • Medicine, Computer Science
  • The Lancet
  • Parkinson's disease is a common progressive bradykinetic disorder that can be accurately diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions. The main known risk factor is age. Susceptibility genes including alpha-synuclein, leucine rich repeat kinase 2 (LRRK-2), and glucocerebrosidase (GBA) have shown that genetic predisposition is another important… CONTINUE READING
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