Parkinson's disease

@article{Lees2006ParkinsonsD,
  title={Parkinson's disease},
  author={A. Lees and J. Hardy and T. Revesz},
  journal={The Lancet},
  year={2006},
  volume={373},
  pages={2055-2066}
}
  • A. Lees, J. Hardy, T. Revesz
  • Published 2006
  • Medicine, Computer Science
  • The Lancet
  • Parkinson's disease is a common progressive bradykinetic disorder that can be accurately diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions. The main known risk factor is age. Susceptibility genes including alpha-synuclein, leucine rich repeat kinase 2 (LRRK-2), and glucocerebrosidase (GBA) have shown that genetic predisposition is another important… CONTINUE READING
    383 Citations
    Often overlooked neuropsychiatric syndromes in Parkinson's disease
    • 1
    • PDF
    Medical management of Parkinson's disease.
    • M. Goldenberg
    • Medicine
    • P & T : a peer-reviewed journal for formulary management
    • 2008
    • 91
    • PDF
    α-Synuclein in the olfactory system in Parkinson’s disease: role of neural connections on spreading pathology
    • 41
    • Highly Influenced
    Biomarkers of Parkinson's disease: present and future.
    • 183
    Recent advances in Parkinson’s disease genetics
    • 60
    1 Update in Parkinson ’ s Disease
    • PDF
    The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
    • M. Cookson
    • Biology, Medicine
    • Nature Reviews Neuroscience
    • 2010
    • 437