Parkinson's disease: genetics and pathogenesis.

@article{Shulman2011ParkinsonsDG,
  title={Parkinson's disease: genetics and pathogenesis.},
  author={Joshua M. Shulman and Philip L. De Jager and Mel B. Feany},
  journal={Annual review of pathology},
  year={2011},
  volume={6},
  pages={
          193-222
        }
}
Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable insight while simultaneously challenging traditional conceptual frameworks. Although the disease remains defined clinically by its cardinal motor manifestations and pathologically by midbrain dopaminergic cell loss in association with Lewy bodies, it is now recognized that PD has substantially more widespread impact, causing a host of nonmotor symptoms and associated pathology in multiple regions… 
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Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.
TLDR
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