Parkinson's disease: genetics and pathogenesis.

@article{Shulman2011ParkinsonsDG,
  title={Parkinson's disease: genetics and pathogenesis.},
  author={J. Shulman and P. De Jager and Mel B. Feany},
  journal={Annual review of pathology},
  year={2011},
  volume={6},
  pages={
          193-222
        }
}
  • J. Shulman, P. De Jager, Mel B. Feany
  • Published 2011
  • Biology, Medicine
  • Annual review of pathology
  • Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable insight while simultaneously challenging traditional conceptual frameworks. Although the disease remains defined clinically by its cardinal motor manifestations and pathologically by midbrain dopaminergic cell loss in association with Lewy bodies, it is now recognized that PD has substantially more widespread impact, causing a host of nonmotor symptoms and associated pathology in multiple regions… CONTINUE READING
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