Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion‐Like Disorder?

@article{Olanow2013ParkinsonsDA,
  title={Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion‐Like Disorder?},
  author={C. Warren Olanow and Patrik Brundin},
  journal={Movement Disorders},
  year={2013},
  volume={28}
}
Altered protein handling is thought to play a key role in the etiopathogenesis of Parkinson's disease (PD), as the disorder is characterized neuropathologically by the accumulation of intraneuronal protein aggregates (Lewy bodies and Lewy neurites). Attention has particularly focused on the α‐synuclein protein, as it is the principal component of Lewy pathology. Moreover, point mutations in the α‐synuclein gene cause rare familial forms of PD. Importantly, duplication/triplication of the wild… Expand
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