Parkinson's Disease Mechanisms and Models

  title={Parkinson's Disease Mechanisms and Models},
  author={W. Dauer and S. Przedborski},
  • W. Dauer, S. Przedborski
  • Published 2003
  • Biology, Medicine
  • Neuron
  • Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular events that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD… CONTINUE READING
    4,165 Citations
    Neuronal pathology in Parkinson’s disease
    • J. Schulz
    • Biology, Medicine
    • Cell and Tissue Research
    • 2005
    • 89
    • PDF
    Pathogenesis of nigral cell death in Parkinson's disease.
    • 171
    Neurodegenerative signaling factors and mechanisms in Parkinson's pathology.
    • P. Goswami, N. Joshi, S. Singh
    • Biology, Medicine
    • Toxicology in vitro : an international journal published in association with BIBRA
    • 2017
    • 24
    Parkinson's Disease: A Review about Pathogenesis, Treatment and Experimental Models
    • Highly Influenced
    • PDF
    Parkinson’s disease: animal models and dopaminergic cell vulnerability
    • 291
    • PDF
    Molecular pathophysiology of Parkinson's disease.
    • 1,079
    • PDF
    Ubiquitin-proteasome system dysfunction in experimental models of Parkinson's disease
    • 1
    • Highly Influenced
    Early synaptic dysfunction in Parkinson's disease: Insights from animal models
    • 70


    p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    • 191
    Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
    • W. Dauer, N. Kholodilov, +14 authors R. Hen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 525
    • PDF
    Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • 1,120
    Parkinson's disease
    • 220
    Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • 691
    An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage
    • 551
    • PDF
    Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
    • A. Hartmann, S. Hunot, +10 authors E. Hirsch
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 623
    • PDF