Parkinson's Disease Mechanisms and Models

@article{Dauer2003ParkinsonsDM,
  title={Parkinson's Disease Mechanisms and Models},
  author={W. Dauer and S. Przedborski},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={889-909}
}
  • W. Dauer, S. Przedborski
  • Published 2003
  • Biology, Medicine
  • Neuron
  • Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular events that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD… CONTINUE READING
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    References

    SHOWING 1-10 OF 260 REFERENCES
    p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    • 191
    Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
    • W. Dauer, N. Kholodilov, +14 authors R. Hen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 525
    • PDF
    Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • 1,120
    Parkinson's disease
    • 220
    Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • 691
    An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage
    • 551
    • PDF
    Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
    • A. Hartmann, S. Hunot, +10 authors E. Hirsch
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 623
    • PDF