Parkinson's Disease Mechanisms and Models
@article{Dauer2003ParkinsonsDM, title={Parkinson's Disease Mechanisms and Models}, author={W. Dauer and S. Przedborski}, journal={Neuron}, year={2003}, volume={39}, pages={889-909} }
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular events that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD… CONTINUE READING
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