• DOI:10.1016/S0896-6273(03)00568-3
Corpus ID: 10400095

Parkinson's Disease Mechanisms and Models

@article{Dauer2003ParkinsonsDM,
  title={Parkinson's Disease Mechanisms and Models},
  author={W. Dauer and S. Przedborski},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={889-909}
}

W. Dauer, S. Przedborski

Published 2003

Biology, Medicine

Neuron

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular events that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD… CONTINUE READING

View on Elsevier

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed