Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

@inproceedings{Ciccone2013ParkinsonsDA,
  title={Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress},
  author={Sarah Ciccone and Emiliano Maiani and Giovanna Bellusci and Marc Diederich and Stefania Gonfloni},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in… CONTINUE READING
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