Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

@inproceedings{Tsika2014ParkinsonsDM,
  title={Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration},
  author={Elpida Tsika and Liliane Glauser and Roger Moser and Aris Fiser and Guillaume Daniel and U M Sheerin and Andrew Lees and Juan C Troncoso and Patrick A. Lewis and Rina Bandopadhyay and Bernard L Schneider and Darren Moore},
  booktitle={Human molecular genetics},
  year={2014}
}
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the pathogenic consequences of PD-associated mutations in VPS35 using a number of model systems. VPS35 exhibits a broad neuronal distribution throughout the rodent brain, including within the nigrostriatal dopaminergic pathway. In the human brain… CONTINUE READING

Citations

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VPS 35 , the Retromer Complex and Parkinson ’ s Disease

Erin T. Williamsa, Xi Chena, Darren J. Moorea, Darren. Moore
2017
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Retromer in Synaptic Function and Pathology

Front. Synaptic Neurosci. • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Processing of human cathepsin D in lysosomes in vitro.

The Journal of biological chemistry • 1985
View 11 Excerpts
Highly Influenced

Pathogenic Mutation in VPS35 Impairs Its Protection against MPP+ Cytotoxicity

International journal of biological sciences • 2013
View 4 Excerpts
Highly Influenced

The VPS35 gene and Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society • 2013
View 3 Excerpts
Highly Influenced

VPS35 mutations in Parkinson disease.

American journal of human genetics • 2011
View 4 Excerpts
Highly Influenced

Mendelian forms of Parkinson's disease.

Biochimica et biophysica acta • 2009
View 10 Excerpts
Highly Influenced

Alpha-synuclein in Lewy bodies.

View 11 Excerpts
Highly Influenced

RAB 7 L 1 interacts with LRRK 2 to modify intraneuronal protein sorting and Parkinson ’ s disease risk

D. A. MacLeod, H. Rhinn, +7 authors S. A. Small
2013

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