Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

  title={Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration},
  author={Elpida Tsika and Liliane Glauser and Roger Moser and Aris Fiser and Guillaume Daniel and U M Sheerin and Andrew Lees and Juan C Troncoso and Patrick A. Lewis and Rina Bandopadhyay and Bernard L Schneider and Darren Moore},
  booktitle={Human molecular genetics},
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the pathogenic consequences of PD-associated mutations in VPS35 using a number of model systems. VPS35 exhibits a broad neuronal distribution throughout the rodent brain, including within the nigrostriatal dopaminergic pathway. In the human brain… CONTINUE READING


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