Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions.

@article{Witte2009ParkinsonsDP,
  title={Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions.},
  author={Maarten E. Witte and John G. J. M. Bol and Wouter H. Gerritsen and P van der Valk and Benjamin Drukarch and Jack van Horssen and Micha M. M. Wilhelmus},
  journal={Neurobiology of disease},
  year={2009},
  volume={36 3},
  pages={445-52}
}
Parkin is implicated in the pathogenesis of Parkinson's disease. Furthermore, parkin targets misfolded proteins for degradation and protects cells against various forms of cellular stress, including unfolded-protein and oxidative stress. This points towards a protective role of parkin in neurological disorders in which these stressors are implicated, including Alzheimer's disease (AD) and multiple sclerosis (MS). Here, we assessed parkin distribution in AD and MS brain tissue using… CONTINUE READING