Parkinson's disease and other alpha-synucleinopathies.

  title={Parkinson's disease and other alpha-synucleinopathies.},
  author={Michel Goedert},
  journal={Clinical chemistry and laboratory medicine},
  volume={39 4},
  • Michel Goedert
  • Published 2001 in Clinical chemistry and laboratory medicine
Parkinson's disease is the most common movement disorder and the second most common neurodegenerative disease. Neuropathologically, it is characterized by the degeneration of nerve cells that develop filamentous inclusions in the form of Lewy bodies and Lewy neurites. Recent work has shown that rare, familial forms of Parkinson's disease are caused by missense mutations in the alpha-synuclein gene and that the filamentous lesions of Parkinson's disease are made of alpha-synuclein. The same is… CONTINUE READING