Parkinson's disease and inflammatory changes

  title={Parkinson's disease and inflammatory changes},
  author={Carlos Barcia and Andr{\'e}s Fern{\'a}ndez Barreiro and M. Poza y Poza and M. A. Herrero},
  journal={Neurotoxicity Research},
In 1988 McGeer and colleagues (Neurology 38, 1285–91) observed an activation of the microglia in substantia nigrapars compacta (SNpc) and striatum of brains from patients with Parkinson's disease. In the years that followed several studies performed in the cerebrospinal fluid and duringpost-mortem analysis in parkinsonian patients revealed increased levels of cytokines, suggesting the activation of a proinflammatory response. Moreover, Langston and his group described the presence of active… CONTINUE READING


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