Parkinson's disease--redox mechanisms.

@article{Adams2001ParkinsonsDM,
  title={Parkinson's disease--redox mechanisms.},
  author={James David Adams and Mei Ling Chang and Lori K. Klaidman},
  journal={Current medicinal chemistry},
  year={2001},
  volume={8 7},
  pages={
          809-14
        }
}
Parkinson's disease occurs in 1% of people over the age of 65 when about 60% of the dopaminergic neurons in the substantia nigra of the midbrain are lost. Dopaminergic neurons appear to die by a process of apoptosis that is induced by oxidative stress. Oxygen radicals abstract hydrogen from DNA forming DNA radicals that lead to DNA fragmentation, activation of DNA protective mechanisms, NAD depletion and apoptosis. Oxygen radicals can be formed in dopaminergic neurons by redox cycling of MPP… CONTINUE READING

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