Parkinson's disease, Alzheimer's disease and motor neurone disease: identifying a common mechanism.

@article{Greenfield2002ParkinsonsDA,
  title={Parkinson's disease, Alzheimer's disease and motor neurone disease: identifying a common mechanism.},
  author={Sarah Greenfield and David J T Vaux},
  journal={Neuroscience},
  year={2002},
  volume={113 3},
  pages={485-92}
}
Although Alzheimer's disease, Parkinson's disease, and motor neurone disease are distinct disorders, there could be a common neurodegenerative mechanism that characterises the death of selective neurone populations in each case. We propose that this mechanism could be an aberrantly activated, developmental process involving a non-classical, non-enzymatic action of acetylcholinesterase mediated via a short linear motif near the C-terminal end of the molecule. Since this motif has a highly… CONTINUE READING

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