Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.

@article{Rosen2010ParkinRI,
  title={Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.},
  author={K. M. Rosen and Charbel E-H Moussa and Han-Kyu Lee and Pravir Kumar and Tohru Kitada and Gangjian Qin and Qinghao Fu and Henry W. Querfurth},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 1},
  pages={167-78}
}
The significance of intracellular beta-amyloid (Abeta(42)) accumulation is increasingly recognized in Alzheimer's disease (AD) pathogenesis. Abeta removal mechanisms that have attracted attention include IDE/neprilysin degradation and antibody-mediated uptake by immune cells. However, the role of the ubiquitin-proteasome system (UPS) in the disposal of cellular Abeta has not been fully explored. The E3 ubiquitin ligase Parkin targets several proteins for UPS degradation, and Parkin mutations… CONTINUE READING
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…