Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans.

@article{Valenci2015ParkinMH,
  title={Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans.},
  author={Itay Valenci and Lital Yonai and Dan Bar-Yaacov and Dan Mishmar and Anat Ben-Zvi},
  journal={Mitochondrion},
  year={2015},
  volume={20},
  pages={64-70}
}
Parkin, which is mutated in most recessive Parkinsonism, is a key player in the selective removal of damaged mitochondria via mitophagy. Damaged mitochondria may carry mitochondrial DNA (mtDNA) mutations, thus creating a mixed mtDNA population within cells (heteroplasmy). It was previously shown that Parkin over-expression reduced the level of heteroplasmic mutations that alter mitochondrial membrane potential in human cytoplasmic hybrids. However, it remained unclear whether Parkin serves a… CONTINUE READING