Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

  title={Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice},
  author={Guohua Gong and Moshi Song and Gyorgy Csordas and D. P. Kelly and Scot J Matkovich and Gerald W. Dorn},
In developing hearts, changes in the cardiac metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohydrates to fatty acids. Mechanisms responsible for this mitochondrial plasticity are unknown. Here, we found that PINK1-Mfn2-Parkin–mediated mitophagy directs this metabolic transformation in mouse hearts. A mitofusin (Mfn) 2 mutant lacking PINK1 phosphorylation sites necessary for Parkin binding (Mfn2 AA) inhibited mitochondrial Parkin translocation… CONTINUE READING
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