Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

@article{Gong2015ParkinmediatedMD,
  title={Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice},
  author={Guohua Gong and Moshi Song and Gyorgy Csordas and D. P. Kelly and Scot J Matkovich and Gerald W. Dorn},
  journal={Science},
  year={2015},
  volume={350}
}
In developing hearts, changes in the cardiac metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohydrates to fatty acids. Mechanisms responsible for this mitochondrial plasticity are unknown. Here, we found that PINK1-Mfn2-Parkin–mediated mitophagy directs this metabolic transformation in mouse hearts. A mitofusin (Mfn) 2 mutant lacking PINK1 phosphorylation sites necessary for Parkin binding (Mfn2 AA) inhibited mitochondrial Parkin translocation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 39 times over the past 90 days. VIEW TWEETS
49 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Noncanonical functioning of dynamism factors in static mitochondria of the heart

  • M. Song, G. W. Dorn 2nd, Mitoconfusion
  • Cell Metab. 21, 195–205
  • 2015
1 Excerpt

2 nd , Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin

  • J. A. Williams
  • Circ . Res .
  • 2014

Similar Papers

Loading similar papers…