Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells.

  title={Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells.},
  author={Min Ho Lee and Yoonjung Cho and Byung Chul Jung and Sung-Hoon Kim and Yeo Wool Kang and Cheol-Ho Pan and Ki-Jong Rhee and Yoon Suk Kim},
  journal={Biochemical and biophysical research communications},
  volume={464 1},
Parkin is a known tumor suppressor. However, the mechanism by which parkin acts as a tumor suppressor remains to be fully elucidated. Previously, we reported that parkin expression induces caspase-dependent apoptotic cell death in TNF-α-treated HeLa cells. However, at that time, we did not consider the involvement of parkin in cell cycle control. In the current study, we investigated whether parkin is involved in cell cycle regulation and suppression of cancer cell growth. In our cell cycle… CONTINUE READING


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