Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter.

  title={Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter.},
  author={Houbo Jiang and Qian Jiang and Jian Feng},
  journal={The Journal of biological chemistry},
  volume={279 52},
Mutations of parkin, a protein-ubiquitin E3 ligase, are linked to Parkinson's disease (PD). Although a variety of parkin substrates have been identified, none of these is selectively expressed in dopaminergic neurons, whose degeneration plays a critical role in PD. Here we show that parkin significantly increased dopamine uptake in the human dopaminergic neuroblastoma cell line SH-SY5Y. This effect was accompanied by increased V(max) of dopamine uptake and unchanged K(m). Consistent with this… CONTINUE READING


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