Parkin genetics: one model for Parkinson's disease.

  title={Parkin genetics: one model for Parkinson's disease.},
  author={Ignacio Fernandez Mata and Paul J Lockhart and Matthew John Farrer},
  journal={Human molecular genetics},
  volume={13 Spec No 1},
The genetic epidemiology of late-onset idiopathic Parkinson's disease (PD) and 'parkin-proven' parkinsonism (AR-JP) are limited. The clinical phenotype, prognosis and treatments are similar although PD is prevalent while AR-JP is rare. Molecular genetic and functional analysis suggests the E3 ubiquitin protein ligase activity of parkin, and the ubiquitin-proteosomal pathway, is central to disease pathogenesis. Herein, we compare and contrast PD and AR-JP and discuss the implications of recent… CONTINUE READING

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