Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.

@article{Sun2013ParkinDC,
  title={Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.},
  author={Xiaodong Sun and Min Liu and J. T. Hao and Dengwen Li and Youguang Luo and Xiuchao Wang and Yunfan Yang and Fang Li and Wenqing Shui and Quan Chen and Jun Zhou},
  journal={Cell cycle},
  year={2013},
  volume={12 7},
  pages={1133-41}
}
Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development of pancreatic cancer, the fourth leading cause of cancer-related deaths worldwide. Herein, we demonstrate the downregulation and copy number loss of the parkin gene in human pancreatic cancer specimens. The expression of parkin negatively… CONTINUE READING