Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.

@article{Meka2015ParkinCW,
  title={Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.},
  author={Durga Praveen Meka and Anne Kathrin M{\"u}ller-Rischart and Prakash Nidadavolu and Behnam Mohammadi and Elisa Motori and Srinivas Kumar Ponna and Helia Aboutalebi and Mahmoud Bassal and Anil Annamneedi and B. Finckh and Margit Miesbauer and Natalie Rotermund and Christian Lohr and J{\"o}rg Tatzelt and Konstanze F Winklhofer and Edgar R Kramer},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 5},
  pages={1873-85}
}
Parkin and the glial cell line-derived neurotrophic factor (GDNF) receptor RET have both been independently linked to the dopaminergic neuron degeneration that underlies Parkinson's disease (PD). In the present study, we demonstrate that there is genetic crosstalk between parkin and the receptor tyrosine kinase RET in two different mouse models of PD. Mice… CONTINUE READING