Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.

@article{Ansari2018ParkinCO,
  title={Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.},
  author={Mohammad Yunus Ansari and Nazir M. Khan and Imran Ahmad and Tariq M Haqqi},
  journal={Osteoarthritis and cartilage},
  year={2018},
  volume={26 8},
  pages={
          1087-1097
        }
}
OBJECTIVE Mitochondrial dysfunction, oxidative stress and chondrocyte death are important contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we determined the expression and role of Parkin in the clearance of damaged/dysfunctional mitochondria, regulation of reactive oxygen species (ROS) levels and chondrocyte survival under pathological conditions. METHODS Human chondrocytes were from the unaffected area of knee OA cartilage (n = 12) and were stimulated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS