Parkin Regulates the Activity of Pyruvate Kinase M2.

  title={Parkin Regulates the Activity of Pyruvate Kinase M2.},
  author={Kun Liu and Fanzhou Li and Haichao Han and Yue Chen and Ze-bin Mao and Jianyuan Luo and Yingming Zhao and Bin Zheng and Wei Yong Gu and Wenhui Zhao},
  journal={The Journal of biological chemistry},
  volume={291 19},
Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique substrate for parkin through biochemical purification. We found that parkin interacts with PKM2 both in vitro and in vivo, and this interaction dramatically increases during glucose starvation… CONTINUE READING


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Pkm2 10316 Journal of Biological Chemistry Volume

  • K. Aldape, L. C. Cantley, Z. Lu
  • MAY
  • 2016
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