Parkin’s substrates and the pathways leading to neuronal damage

@article{Cookson2003ParkinsSA,
  title={Parkin’s substrates and the pathways leading to neuronal damage},
  author={Mark R Cookson},
  journal={NeuroMolecular Medicine},
  year={2003},
  volume={3},
  pages={1-13}
}
Mutations in the Parkin gene are associated with Parkinson’s disease (PD). The gene product has been shown to be an E3 protein-ubiquitin ligase, catalyzing the addition of ubiquitin to target proteins prior to their destruction via the proteasome. This activity is thus key in regulating the turnover of substrate proteins. A predictive hypothesis for how this results in PD is that the misregulation of proteasomal degradation of Parkin’s substrates is deleterious to neurons. Several different… CONTINUE READING
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