Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.

@article{Zhang2011ParkinAP,
  title={Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.},
  author={Cen Zhang and Meihua Lin and Rui Wu and Xiaowen Wang and Bo Yang and Arnold J. Levine and Wenwei Hu and Zhaohui Feng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 39},
  pages={16259-64}
}
Regulation of energy metabolism is a novel function of p53 in tumor suppression. Parkin (PARK2), a Parkinson disease-associated gene, is a potential tumor suppressor whose expression is frequently diminished in tumors. Here Parkin was identified as a p53 target gene that is an important mediator of p53's function in regulating energy metabolism. The human and mouse Parkin genes contain functional p53 responsive elements, and p53 increases the transcription of Parkin in both humans and mice… CONTINUE READING
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