Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression

@article{Boulanger2005ParityinducedMM,
  title={Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression},
  author={Corinne A Boulanger and K M Wagner and Gilbert H Smith},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={552-560}
}
A parity-induced mammary population, marked by β-galactosidase expression conditionally activated through cre-lox recombinase originates in WAP-Cre/Rosa-lox-STOP-lox-LacZ (WAP-Cre/Rosa-LacZ) female mice during pregnancy, lactation and involution. During subsequent pregnancies, these parity-induced mammary epithelial cells (PI-MEC) proliferated to produce new secretory acini composed of secretory luminal cells and myoepithelium. In serial transplantation assays, PI-MEC were able to self-renew… CONTINUE READING
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