Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.

@article{LpezDaz2006ParietalCH,
  title={Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.},
  author={Lymari L{\'o}pez-D{\'i}az and Karen L. Hinkle and Renu N. Jain and Yana Zavros and Cynthia S. Brunkan and Theresa M. Keeley and Kathryn A. Eaton and Juanita L Merchant and Catherine S. Chew and Linda C. Samuelson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 5},
  pages={
          G970-9
        }
}
The stimulation of gastric acid secretion from parietal cells involves both intracellular calcium and cAMP signaling. To understand the effect of increased cAMP on parietal cell function, we engineered transgenic mice expressing cholera toxin (Ctox), an irreversible stimulator of adenylate cyclase. The parietal cell-specific H(+),K(+)-ATPase beta-subunit promoter was used to drive expression of the cholera toxin A1 subunit (CtoxA1). Transgenic lines were established and tested for Ctox… CONTINUE READING

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