Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.

@article{Tan2006ParicalcitolAR,
  title={Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.},
  author={Xiaoyue Tan and Yingjian Li and Youhua Liu},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 12},
  pages={3382-93}
}
Deficiency in vitamin D and its active metabolites is a pathologic feature of chronic kidney diseases. Despite that tubular epithelial cells are the major sites of active vitamin D synthesis, little is known about the role of vitamin D in maintaining the structural and functional integrity of tubular epithelium. This study investigated the effects of paricalcitol (19-nor-1,25-hydroxy-vitamin D(2)), a synthetic vitamin D analogue, on obstructive nephropathy, a model that is characterized by… CONTINUE READING
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