Pargyline prevents MPTP-induced parkinsonism in primates.

  title={Pargyline prevents MPTP-induced parkinsonism in primates.},
  author={James William Langston and Ian Irwin and E B Langston and Lysia S. Forno},
  volume={225 4669},
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin which produces permanent parkinsonism in human and nonhuman primates. Treatment of squirrel monkeys with pargyline, a monoamine oxidase (MAO) inhibitor, prevents both clinical and neuropathological evidence of the neurotoxic effects of MPTP. Pargyline also inhibits conversion of MPTP to 1-methyl-4-phenylpyridinium ion (MPP+), a metabolic step that occurs rapidly after administration of MPTP in animals not treated with pargyline… CONTINUE READING


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