Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats.

  title={Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats.},
  author={Mark J. Koruda and Rolando H. Rolandelli and Donna Z Bliss and Jon R Hastings and John L. Rombeau and R G Settle},
  journal={The American journal of clinical nutrition},
  volume={51 4},
When enteral nutrition is excluded from animals maintained solely with total parenteral nutrition (TPN), atrophy of the intestinal mucosa is observed. Short-chain fatty acids (SCFAs) are produced in the colon by the fermentation of dietary carbohydrates and fiber polysaccharides and have been shown to stimulate mucosal-cell mitotic activity in the intestine. This study compared the effects of an intravenous and an intracecal infusion of SCFAs on the small-bowel mucosa. Rats received standard… CONTINUE READING
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