Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults.

@article{Guthrie2004ParenteralIV,
  title={Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults.},
  author={Terry Guthrie and Christopher G. L. Hobbs and Victoria Davenport and Rachel E. Horton and Robert S Heyderman and Neil Arnold Williams},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 11},
  pages={
          1927-35
        }
}
We sought to determine whether palatine tonsils (PTs) harbor naturally acquired influenza-specific T cell immunity and whether routine parenteral immunization with influenza vaccine influences mucosal and systemic T cell reactivity. We demonstrate that tonsillar and peripheral blood mononuclear cells (PBMCs) proliferate strongly to influenza antigens, suggesting that naturally acquired immunity exists within both the mucosal and systemic compartments. Influenza vaccination induced significantly… CONTINUE READING
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