Parenteral formulation of hexamethylmelamine potentially suitable for use in man.

Abstract

We have developed a preparation of hexamethylmelamine (HMM), dissolved in a fat emulsion Intralipid 20%, that is potentially satisfactory for parenteral administration to man. Solid HMM can be dissolved in Intralipid 20% up to 5 mg/ml, with extensive agitation. Solubilization of HMM is facilitated first by dissolving the drug in ethanol or in dimethylacetamide and then by adding the solution to Intralipid 20%. The disposition of HMM in rabbits after iv administration of HMM dissolved in Intralipid 20% was similar to the disposition of the drug following iv administration of HMM dissolved in 0.1 N HCl.

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@article{Ames1982ParenteralFO, title={Parenteral formulation of hexamethylmelamine potentially suitable for use in man.}, author={Matthew Ames and John S. Kovach}, journal={Cancer treatment reports}, year={1982}, volume={66 7}, pages={1579-81} }