Parenteral formulation of hexamethylmelamine potentially suitable for use in man.

@article{Ames1982ParenteralFO,
  title={Parenteral formulation of hexamethylmelamine potentially suitable for use in man.},
  author={Matthew Ames and John S. Kovach},
  journal={Cancer treatment reports},
  year={1982},
  volume={66 7},
  pages={
          1579-81
        }
}
We have developed a preparation of hexamethylmelamine (HMM), dissolved in a fat emulsion Intralipid 20%, that is potentially satisfactory for parenteral administration to man. Solid HMM can be dissolved in Intralipid 20% up to 5 mg/ml, with extensive agitation. Solubilization of HMM is facilitated first by dissolving the drug in ethanol or in dimethylacetamide and then by adding the solution to Intralipid 20%. The disposition of HMM in rabbits after iv administration of HMM dissolved in… CONTINUE READING

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