Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism.

@article{Kupetz2013ParenteralFO,
  title={Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism.},
  author={Eva Kupetz and Lutz Preu and Conrad Kunick and Heike Bunjes},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2013},
  volume={85 3 Pt A},
  pages={
          511-20
        }
}
  • E. Kupetz, L. Preu, +1 author H. Bunjes
  • Published 1 November 2013
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
The paullon chalcone derivative KuRei300 is active against Leishmania donovani, the protozoans causing visceral leishmaniasis. The aim of this study was the development of a parenteral formulation of the virtually water insoluble compound in order to enable future studies in mice. Mixed lecithin/bile salt micelles, liposomes, supercooled smectic cholesterol myristate nanoparticles, cubic phase nanoparticles and a triglyceride emulsion were screened for their solubilizing properties. Due to the… 
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Carrier characteristics influence the kinetics of passive drug loading into lipid nanoemulsions
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Graphical abstract Figure. No caption available. ABSTRACT When using lipid nanoparticles as drug carrier system it is important to know how much drug can be loaded to the nanoparticles. The mainly
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Mixtures of lecithin and bile salt can form highly viscous wormlike micellar solutions in water.
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It is shown that lecithin-bile salt micelles can be further induced to grow into long, flexible wormlike structures and postulate a mechanism based on changes in the molecular geometry caused by bile salts and electrolytes to explain the micellar growth.
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