Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.

  title={Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.},
  author={Nermi L Parrow and Jonathan A Leshin and Mark Levine},
  journal={Antioxidants & redox signaling},
  volume={19 17},
SIGNIFICANCE Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific communities to dismiss the use of ascorbate as a potential cancer treatment. However, the route of administration results in major differences in ascorbate bioavailability. Tissue and… CONTINUE READING
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