Parenteral Clozapine (Clozaril)

@article{McLean2001ParenteralC,
  title={Parenteral Clozapine (Clozaril)},
  author={Greg McLean and L. M. Juckes},
  journal={Australasian Psychiatry},
  year={2001},
  volume={9},
  pages={371 - 371}
}

Combination With Long-Acting Injectable Antipsychotics and Utilization of Nonstandard Formulations as Compliance Enhancing Methods for Clozapine Users

In a case series, illness severity and the number of hospitalization per year significantly decreased after the combined treatment, besides a significant improvement in the functioning scores, and oral-dissolving tablets or oral liquid formulations of clozapine have insufficient evidence for clinical practice.

Alternative Routes of Administration of Clozapine

The administration of clozapine (suspension or crushed tablets) via enteral feeding tubes (predominantly nasogastric) has been reported both in medically unwell patients and in patients refusing clozAPine, and is likely to be superseded by intramuscular clozal administration.

Clinical Experience With Intramuscular Clozapine

IM clozapine may facilitate successful transition to oral clozAPine in most patients, and it definitely represents a valuable tool for addressing refusal of oral clazapine in patients with treatment-refractory schizophrenia.

A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis.

Intramuscular clozapine prescription allowed transition to oral maintenance in an initially non-adherent cohort of patients in treatment-resistant psychosis over a 3-year period.

Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

It is shown that intramuscular clozapine can be used safely and effectively when the oral route is initially refused, and the use, efficacy and safety of this treatment modality is described.

The assertive approach to clozapine: nasogastric administration

Five of the most extremely ill patients with treatment-resistant schizophrenia were established and/or maintained on clozapine, resulting in improvements to their mental state; incidents were reduced, segregation was terminated and progression to less restrictive environments was achieved.

Compulsory treatment with clozapine: a retrospective long-term cohort study.

References

Parenteral clozapine: five years of experience.