Parental trisomy 21 mosaicism.

  title={Parental trisomy 21 mosaicism.},
  author={David J. Harris and Michael L. Begleiter and Judi Chamberlin and L A Hankins and R. Ellen Magenis},
  journal={American journal of human genetics},
  volume={34 1},
A family with three children with trisomy 21 in which the mother is a phenotypically normal, trisomy 21/normal mosaic was studied. Chromosome 21 fluorescent heteromorphisms were used to document that two of the three number 21's in two of the Down syndrome offspring were of maternal origin. Five cytogenetic surveys in which both parents of a child with… CONTINUE READING