• Biology, Medicine
• Published in Human Genetics 1977
• DOI:10.1007/BF00293766

Parental origin of the extra chromosome in Down's syndrome

@article{Magenis1977ParentalOO,
  title={Parental origin of the extra chromosome in Down's syndrome},
  author={R. Ellen Magenis and K. M. Overton and Judith Chamberlin and Troy Brady and Everett W. Lovrien},
  journal={Human Genetics},
  year={1977},
  volume={37},
  pages={7-16}
}

• R. Ellen Magenis, K. M. Overton, +2 authors Everett W. Lovrien

SummaryChromosome 21 fluorescent heteromorphisms were studied in 42 patients with Down's syndrome, their parents and their siblings. Included in this number are two instances of an aunt and niece affected with trisomy 21, and one of affected siblings. One case has a de novo 21/21 translocation. Blood group, red cell and serum protein markers were also studied for linkage, gene exclusions, associations, and paternity testing. Thirty-one of the trisomy 21 cases were informative for parental… CONTINUE READING

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