Parental origin of sequence variants associated with complex diseases

  title={Parental origin of sequence variants associated with complex diseases},
  author={Augustine Kong and Valgerdur Steinthorsdottir and G{\'i}sli M{\'a}sson and Gudmar Thorleifsson and Patrick Sulem and Soren Besenbacher and Aslaug Jonasdottir and Asgeir Sigurdsson and Kari Th. Kristinsson and Adalbjorg Jonasdottir and Michael L Frigge and Arnaldur Gylfason and P{\'a}ll Is{\'o}lfur Olason and Sigurjon Axel Gudjonsson and Sverrir Sverrisson and Simon N. Stacey and Bardur Sigurgeirsson and Kristrun R. Benediktsdottir and Helgi Sigurdsson and Thorvaldur J{\'o}nsson and Rafn Benediktsson and Jon H. Olafsson and Oskar Th. Johannsson and Astradur B. Hreidarsson and Gunnar Sigurdsson and Anne C Ferguson-Smith and Daniel Fannar Gudbjartsson and Unnur Thorsteinsdottir and K{\'a}ri Stef{\'a}nsson},
Effects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be determined. For this we used a combination of genealogy and long-range phasing. We then… CONTINUE READING


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A Catalog of Published Genome-Wide Association Studies

  • LA. Hindorff, HA. Junkins, JP. Mehta, TA. Manolio
  • 2009

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