Parental origin, nondisjunction, and recombination of the extra chromosome 21 in Down syndrome: a study in a sample of the Colombian population.

Abstract

INTRODUCTION Free trisomy 21 is responsible for 95% of Down syndrome cases. Advanced maternal age and susceptible recombination patterns are recognized risk factors associated to Down syndrome. Maternal origin of trisomy occurs in approximately 90% of cases; paternal and mitotic origin share the remaining 10%. However, the recombination events that serve as… (More)

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Cite this paper

@article{Ramrez2007ParentalON, title={Parental origin, nondisjunction, and recombination of the extra chromosome 21 in Down syndrome: a study in a sample of the Colombian population.}, author={Nelson Javier Ram{\'i}rez and Helen Marcela Belalc{\'a}zar and Juan Jos{\'e} Yunis and Luis Napole{\'o}n Quintero and Gonzalo Humberto Arboleda and Humberto Arboleda}, journal={Biomedica : revista del Instituto Nacional de Salud}, year={2007}, volume={27 1}, pages={141-8} }