Parental-origin-determination fluorescence in situ hybridization distinguishes homologous human chromosomes on a single-cell level.

@article{Weise2008ParentalorigindeterminationFI,
  title={Parental-origin-determination fluorescence in situ hybridization distinguishes homologous human chromosomes on a single-cell level.},
  author={Anja Weise and Madeleine M. Gross and Kristin Mrasek and Hasmik H. Mkrtchyan and Bernhard Horsthemke and Christoffer Jonsrud and Ferdinand von Eggeling and Sophie Hinreiner and Vera Witthuhn and Uwe Claussen and Thomas Liehr},
  journal={International journal of molecular medicine},
  year={2008},
  volume={21 2},
  pages={189-200}
}
The differentiation of homologous chromosomes as well as their parental origin can presently be conducted and determined exclusively by molecular genetic methods using microsatellite or SNP analysis. Only in exceptional cases is a distinction on a single-cell level possible, e.g. due to variations within the heterochromatic regions of chromosomes 1, 9, 16 and Y or the p-arms of the acrocentric chromosomes. In the absence of such polymorphisms, an individual distinction of the homologous… CONTINUE READING

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