Parental origin and meiotic stage of non-disjunction in 139 cases of trisomy 21.

@article{Ballesta1999ParentalOA,
  title={Parental origin and meiotic stage of non-disjunction in 139 cases of trisomy 21.},
  author={F. Mart{\'i}nez Ballesta and Rosa Queralt and David Yepes Gomez and Eduardo Gratac{\'o}s Solsona and M{\'i}riam Guitart and Mario Ezquerra and Justo de Jorge Moreno and R. Cuevas Oliva},
  journal={Annales de genetique},
  year={1999},
  volume={42 1},
  pages={
          11-5
        }
}
The parental origin and the meiotic stage of non-disjunction have been determined in 139 Down syndrome patients with regular trisomy 21 and in their parents through the analysis of DNA polymorphism. The meiotic error is maternal in 91.60% cases and paternal in 8.39% of cases. Of the maternal cases, 72.41% were due to meiosis I errors (MMI) and 27.58% were due to meiosis II errors (MMII). Of the paternal cases, 45.45% were due to meiosis I (PMI) and 54.54% were due to meiosis II (PMII). The mean… CONTINUE READING

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