Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos.

@article{Sinclair2013ParentalDP,
  title={Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos.},
  author={K. Sinclair and A. Watkins},
  journal={Reproduction, fertility, and development},
  year={2013},
  volume={26 1},
  pages={
          99-114
        }
}
The periconceptional period, embracing the terminal stages of oocyte growth and post-fertilisation development up to implantation, is sensitive to parental nutrition. Deficiencies or excesses in a range of macro- and micronutrients during this period can lead to impairments in fertility, fetal development and long-term offspring health. Obesity and genotype-related differences in regional adiposity are associated with impaired liver function and insulin resistance, and contribute to fatty acid… Expand
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References

SHOWING 1-10 OF 230 REFERENCES
Metabolic and Mitochondrial Dysfunction in Early Mouse Embryos Following Maternal Dietary Protein Intervention1
  • 77
  • PDF
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.
  • 249
  • PDF
Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability
  • 147
  • PDF
Paternal Diet-Induced Obesity Retards Early Mouse Embryo Development, Mitochondrial Activity and Pregnancy Health
  • 109
  • PDF
Adaptive responses of the embryo to maternal diet and consequences for post-implantation development.
  • 55
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
  • 686
  • PDF
Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease1
  • 196
  • PDF
Maternal iron deficiency identifies critical windows for growth and cardiovascular development in the rat postimplantation embryo.
  • 67
  • PDF
The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism.
  • 199
  • PDF
Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
  • 171
  • PDF
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