Parental consanguinity and congenital heart malformations in a developing country

  title={Parental consanguinity and congenital heart malformations in a developing country},
  author={Mona Nabulsi and Hala Tamim and M R Pahlevan Sabbagh and Mounir Y. Obeid and Khaled Yunis and Fadi F. Bitar},
  journal={American Journal of Medical Genetics Part A},
The association between isolated congenital heart defects and consanguinity was examined in 759 Lebanese patients with different types of congenital heart malformations. The subjects were patients of the Children's Cardiac Registry Center (CCRC) at the American University of Beirut Medical Center. The proportion of first‐cousin marriages among cardiac subjects was compared to that of the National Collaborative Perinatal Neonatal Network (NCPNN), after adjusting for the subjects' geographic… 
Parental consanguinity increases congenital heart diseases in South India
For every incidence of parental consanguinity, the risk of birth of a child with CHD increases, and the important role played by segregation of recessive genes in the offspring resulting in the causation of CHDs is emphasized.
Consanguineous marriage and congenital heart defects: A case‐control study in the neonatal period
A familial factor in the multifactorial etiology of CHDs is suggested, and additional epidemiologic and family‐based genetic studies are needed to understand the complex cause of CHD.
Congenital cardiac disease and inbreeding: specific defects escape higher risk due to parental consanguinity
Only some types of congenitally malformed hearts have an increased percentage of parental Consanguinity, suggesting that those types with no increased risk due to parental consanguinity are determined by genetic factors that are X-linked or exclusively autosomal dominant.
The Frequency of Congenital Heart Disorders among Children Issued from Consanguineous Marriages in Khorasan Province, Northeast of Iran
The data revealed that the risk of CHD increases with parental inbreeding, but there was no significant relationship between parents inbreeding and the type ofCHD.
Parental consanguinity increases the risk of congenital malformations
Parental consanguinity is one of the major risk factors for structural, neurological and cardiac anomalies and detection rate of hydrocephalus was highest in second trimester, cleft lip/palate in third trimester and anencephaly in first trimester.
Consanguinity and Risk of Congenital Heart Defects in Bangladesh
Parents’ consanguinity is significantly associated with congenital heart defects in Bangladesh, and children who born to consanguineous parents had 2.5 times risk of developing CHDs compared to those who were not born to conjoined parents.
Consanguinity and the risk of congenital heart disease
The results suggest that the risk for congenital heart disease is increased in consanguineous unions in the studied populations, principally at first‐cousin level and closer, a factor that should be considered in empiric risk estimates in genetic counseling.
Parental consanguinity in Hong Kong.
It is essential that information on the increased risks associated with parental consanguinity is included in genetic counselling for consanguineous couples, so that they can make informed decisions.
Perinatal outcome of congenital heart disease in a population with high consanguinity
The perinatal pattern and outcome of fetuses with congenital heart disease in consanguineous marriages and joint FE clinics detect most CHD with high accuracy are reported, suggesting consanguinity contributes to a higher prevalence of fetal cardiac and non-cardiac malformations.
Pattern of congenital heart disease among Egyptian children: a 3-year retrospective study
Establishment of a national medical birth registry containing all information about all births in Egypt is needed for adequate surveillance and monitoring of perinatal health problems and congenital birth defects so that preventive measures can be early implemented.


Consanguinity and congenital heart disease in Saudi Arabia.
In a population with a high degree of inbreeding, consanguinity may exacerbate underlying genetic risk factors, particularly in the offspring of first cousins, supporting a hypothesis of autosomal recessive gene involvement in congenital heart disease.
Consanguinity and congenital heart disease in the rural Arab population in northern Israel.
This study shows that the genetic influence is an important factor in the etiology of such malformations and differences in CHD frequencies were found to be statistically significant.
Inbreeding and congenital heart diseases in a North Indian population
The present study suggests a genetic influence and also casts doubt on the applicability of a polygenic threshold model to all forms of cardiac malformation.
A study of possible deleterious effects of consanguinity
In conclusion, consanguinity did not result in reproductive wastage, but was found to be an important factor in the causation of specific illnesses in offspring.
Marked parental consanguinity as a cause for increased major malformations in an Israeli Arab community.
The study demonstrates a marked high rate of consanguineous marriages, whose effect leads to a marked increase in major malformations and thus a prominent public health problem in such villages, and requires a unique genetic counseling approach.
Genetic disorders among Palestinian Arabs: 1. Effects of consanguinity.
  • J. Zlotogora
  • Medicine
    American journal of medical genetics
  • 1997
The importance of genetic factors in various congenital malformations, such as neural tube defects and cleft lip/palate or in various forms of infertility, was confirmed by the observation of a significantly higher consanguinity rate in the parents of these patients than is observed in the general population.
Risk factors for congenital heart diseases in Alexandria, Egypt
The results showed that environmental factors vary according to the specific type of congenital heart disease, and the need to instruct the public about the importance of pre-marital counseling and the deleterious effects of various teratogens in the environment is emphasized.
Congenital heart disease and parental consanguinity in South India
Pseudomonas was the dominant pathogen in the skin, ears and conjunctivae in the patient from the first month of life and the patient had multiple organ insensitivity to aldosterone involving also the sweat glands, as demonstrated by the elevated NaCl concentration in the sweat.
Race, consanguinity and social features in Birmingham babies: a basis for prospective study.
The highest prevalence of parental consanguinity was in Pakistani Muslims (69%), whereas in Muslims from other countries it was 23%, and it was less than 1% in non-Muslims and in the majority of consanguineous Muslim pedigrees the degree of inbreeding was greater than that for first cousin parents.
Congenital malformations. A report of a study of series of consecutive births in 24 centres.
A report is presented of a study of births in 24 centres in 16 countries with respect to the occurrence and type of congenital malformations found in stillborn and liveborn infants. In all, the