Parental alcohol consumption and the risk of congenital heart diseases in offspring: An updated systematic review and meta-analysis

@article{Zhang2019ParentalAC,
  title={Parental alcohol consumption and the risk of congenital heart diseases in offspring: An updated systematic review and meta-analysis},
  author={Senmao Zhang and Lesan Wang and Tubao Yang and Lizhang Chen and Lijuan Zhao and T. Wang and Letao Chen and Ziwei Ye and Z. Zheng and J. Qin},
  journal={European Journal of Preventive Cardiology},
  year={2019},
  volume={27},
  pages={410 - 421}
}
Objective The aim of this study was to provide updated evidence to assess the association between parental alcohol consumption and the risk of total congenital heart diseases (CHDs) and specific CHD phenotypes in offspring, and explore the possible dose–response pattern. Methods PubMed, Embase and Chinese databases were searched with an end-date parameter of July 24, 2019 to identify studies meeting pre-stated inclusion criteria. A random-effects model was used to calculate the overall combined… Expand
Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants
TLDR
This umbrella review shows that many environmental factors have substantial evidence in relation to the risk of developing CHD, and more and better-designed studies are needed to establish robust evidence between environmental factors and CHD. Expand
Maternal fever during preconception and conception is associated with congenital heart diseases in offspring
TLDR
It is indicated that maternal fever is significantly associated with the risk of CHDs in offspring, which highlights that preventing maternal fever during the preconception and conception periods play an important role in decreasing the risk Of congenital heart diseases in offspring. Expand
Association of maternal dietary habits and ADIPOQ gene polymorphisms with the risk of congenital heart defects in offspring: a hospital-based case-control study
TLDR
Maternal dietary habits, ADIPOQ gene, and their interactions show a significant association with the risk of CHDs, however, the findings need to be taken with caution, which highlights that more studies are required to further corroborate the findings. Expand
Alcohol Use Disorders and Increased Risk of Adverse Birth Complications and Outcomes: An 11-Year Nationwide Cohort Study
TLDR
It is confirmed that the monitoring of expecting women with a diagnosis of alcohol-related problems may be useful in preventing adverse birth complications, especially when prevalent in the same year as a woman’s delivery. Expand
Parental alcohol exposure and congenital heart diseases in offspring: A causal link with controversial evidence
TLDR
The causal link between maternal alcohol consumption and foetal defects has been definitely established and the pathophysiological link of parental alcohol exposure and CHD in offspring seems unambiguous, but literature appears inadequate to establish a direct association. Expand
First-Trimester Maternal Folic Acid Supplementation Modifies the Effects of Risk Factors Exposures on Congenital Heart Disease in Offspring
  • Yanji Qu, Shao Lin, +11 authors Xiaoqing Liu
  • Medicine
  • Life
  • 2021
This study aimed to examine effect modification of maternal risk factor exposures and congenital heart disease (CHD) by maternal folic acid supplementation (FAS)/non-FAS. We included 8379 CHD casesExpand
The effect of maternal pre-/early-pregnancy BMI and pregnancy smoking and alcohol on congenital heart diseases: a parental negative control study
TLDR
It is shown that maternal, but not paternal, pregnancy smoking is associated with an increase in odds of offspring CHDs, primarily non-severe CHD cases, providing evidence of an intrauterine effect. Expand
Maternal Cardiovascular Health and Adverse Childbirth Outcomes in the United States
TLDR
Clustering of maternal CVD risk factors was significantly associated with adverse childbirth outcomes and was most common in women of color, calling for special attention to this group. Expand
Paternal exposure to recreational drugs before conception and its effect on live-born offspring: A scoping review.
TLDR
A scoping review of the available literature on the outcome of live-born offspring of fathers who were exposed to recreational drugs before conception found that animal studies showed neurocognitive abnormalities, in particular in male offspring. Expand
Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring.
TLDR
Maternal CVH was a more robust predictor of offspring's CVD-free survival than paternal CVH, underscoring the need for clinical and policy interventions that involve mothers to break the intergenerational cycle of CVC-related morbidity and mortality. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 49 REFERENCES
Maternal Alcohol Consumption before and during Pregnancy and the Risks of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis.
TLDR
This meta-analysis provided no positive association between maternal alcohol consumption and risk of CHDs in offspring and conducted stratified and meta-regression analyses to identify the origin of the heterogeneity among studies. Expand
Association between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-analysis of epidemiological observational studies
TLDR
This meta-analysis suggests that maternal alcohol consumption is modestly not associated with the risk of CHDs, however, further investigation is needed to confirm this conclusion. Expand
Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis
TLDR
It is suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association is found for d-Transposition of the Great Arteries. Expand
Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies.
TLDR
It is observed that maternal alcohol intake increased the risk for d-transposition of the great arteries, NTDs, and multiple CLP in infants, by contrast, smoking was associated with a lower risk of N TDs and conotruncal heart defects. Expand
Combined adverse effects of maternal smoking and high body mass index on heart development in offspring: evidence for interaction?
TLDR
Maternal overweight and smoking may have a synergistic adverse effect on the development of the fetal heart and overweight women who wish to become pregnant should be strongly encouraged to stop smoking and to lose weight. Expand
Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies
TLDR
The reported prevalence of CHD globally continues to increase, with evidence of severe unmet diagnostic need in Africa and the recent prevalence in Asia for the first time appears higher than in Europe and America, suggesting higher genetic or environmental susceptibility to CHD among Asian people. Expand
Increased Risk for Congenital Heart Defects in Children Carrying the ABCB1 Gene C3435T Polymorphism and Maternal Periconceptional Toxicants Exposure
TLDR
The C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in a Han Chinese population when the mothers are exposed to phthalates and alkylphenolic compounds during the periconceptional period, particularly for septal defects. Expand
Congenital Heart Disease and Risk of Cardiovascular Disease: A Meta‐Analysis of Cohort Studies
TLDR
This meta‐analysis of cohort studies of CHD found an association of increased risk of CVD in later life, although it cannot be determined whether this association is confounded by a risk factor profile ofCVD among CHD survivors or whether CHD is an independent risk factor. Expand
Risk factors of different congenital heart defects in Guangdong, China
TLDR
Maternal environmental exposures/occupation and perinatal diseases/medication use were dominant risk factors associated with CHDs in Southern China, suggesting that isolated and multiple defects may have different etiologic factors. Expand
Does maternal environmental tobacco smoke interact with social-demographics and environmental factors on congenital heart defects?
TLDR
Mothers exposed to ETS during the first trimester of pregnancy were more likely to have infants with CHD than mothers who did not, and Maternal low education modified the ETS-CHD association on the multiplicative scale. Expand
...
1
2
3
4
5
...